Article
Polymorphisms in the CHIT1 gene: Associations with colorectal cancer.
Oncotarget - 28 Jun 2016
Li Fei-Feng, Yan Peng, Zhao Zhi-Xun, Liu Zheng, Song Da-Wei, Zhao Xing-Wang, Wang Xi-Shan, Wang Gui-Yu, Liu Shu-Lin
Abstract excerpt
Colorectal cancer (CRC) is one of the most common solid tumors worldwide, often associated with inflammation. The microbes in the human intestine have a key role in inflammations and CRC. Chitotriose renders growth advantage to some bacteria, especially some pathogens, and thus has a role in inflammations. The enzyme chitotriosidase, encoded by the CHIT1 gene of the host, may degrade chitotriose with different...
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