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Article

Human chitotriosidase polymorphism is associated with human longevity in Mediterranean nonagenarians and centenarians.

Journal of human genetics - 1 Jan 2010

Malaguarnera Lucia, Ohazuruike Luca Nnawuihe, Tsianaka Christina, Antic Tijana, Di Rosa Michelino, Malaguarnera Mariano

Abstract excerpt

Human phagocyte-specific chitotriosidase (CHIT-1) is a chitinolytic enzyme associated with several diseases involving macrophage activation. Previous studies have demonstrated that a high activity of Chit could have widespread effects on atherosclerosis, cardiovascular disease and dementia. The 24-bp duplication in the CHIT-1 gene is associated with a deficiency in enzymatic activity. In this study, we attempted...

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PMID: 19881466
DOI: 10.1038/jhg.2009.111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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