Article
Mechanisms of innate immune activation by gluten peptide p31-43 in mice.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jul 2016
Araya Romina E, Gomez Castro María Florencia, Carasi Paula, McCarville Justin L, Jury Jennifer, Mowat Allan M, Verdu Elena F, Chirdo Fernando G
Abstract excerpt
Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Innate immunity contributes to the pathogenesis of CD, but the mechanisms remain poorly understood. Although previous in vitro work suggests that gliadin peptide p31-43 acts as an innate immune trigger, the underlying pathways are unclear and have not been explored in vivo. Here we show that...
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