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Article

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease

28 Nov 2018

Abstract excerpt

1 immune and antibody response leading to celiac disease. Prior epithelial stress and innate immune activation are essential for breaking oral tolerance to the gluten component gliadin. How gliadin subverts host intestinal mucosal defenses remains elusive. Here, we show that the α-gliadin-derived LGQQQPFPPQQPY peptide (P31-43) inhibits the function of cystic fibrosis transmembrane conductance regulator (CFTR), an...

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PMID: 30498130
DOI: 10.15252/embj.2018100101

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