Article
The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer.
The oncologist - 1 Jun 2016
Castro Elena, Mikropoulos Christos, Bancroft Elizabeth K, Dadaev Tokhir, Goh Chee, Taylor Natalie, Saunders Edward, Borley Nigel, Keating Diana, Page Elizabeth C, Saya Sibel, Hazell Stephen, Livni Naomi, deSouza Nandita, Neal David, Hamdy Freddie C, Kumar Pardeep, Antoniou Antonis C, Kote-Jarai Zsofia, Eeles Rosalind A
Abstract excerpt
BACKGROUND: A better assessment of individualized prostate cancer (PrCa) risk is needed to improve screening. The use of the prostate-specific antigen (PSA) level for screening in the general population has limitations and is not currently advocated. Approximately 100 common single nucleotide polymorphisms (SNPs) have been identified that are associated with the risk of developing PrCa. The PROFILE pilot study...
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