Article
Genetic predisposition to prostate cancer: an update.
Familial cancer - 1 Jan 2022
Ni Raghallaigh Holly, Eeles Rosalind
Abstract excerpt
Improvements in DNA sequencing technology and discoveries made by large scale genome-wide association studies have led to enormous insight into the role of genetic variation in prostate cancer risk. High-risk prostate cancer risk predisposition genes exist in addition to common germline variants conferring low-moderate risk, which together account for over a third of familial prostate cancer risk. Identifying men...
Topics
- Early Detection of Cancer
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Prospective Studies
- Prostate-Specific Antigen
- Prostatic Neoplasms