Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

5 May 2016

Abstract excerpt

Glucose homeostasis greatly depends on the match between fluctuating insulin demands and adjusted rates of insulin secretion, which is the function of pancreatic beta cells. Emerging evidence suggests that when neonatal beta cells mature, they acquire two faces of differentiated function: an expected "visible face" that depends on specific beta cell proteins needed for regulated insulin release, but also a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27146011
DOI: 10.1146/annurev-nutr-071715-050808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta CellsPMID 27146011Read ↗

Transcription factors that shape the mammalian pancreasSemantic proximity Read ↗

Epigenetics in formation, function, and failure of the endocrine pancreas.Semantic proximity Read ↗

Functional implications of long non-coding RNAs in the pancreatic islets of LangerhansSemantic proximity Read ↗

Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function.Semantic proximity Read ↗

Generation of human islet cell type-specific identity genesetsSemantic proximity Read ↗

A pro-endocrine pancreatic transcriptional program established during development is retained in human gallbladder epithelial cellsSemantic proximity Read ↗

Does epigenetic dysregulation of pancreatic islets contribute to impaired insulin secretion and type 2 diabetes?Semantic proximity Read ↗

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cellsSemantic proximity Read ↗

Lipid droplets protect human β cells from lipotoxic-induced stress and cell identity changesSemantic proximity Read ↗

Not the second fiddle: α cell development, identity, and function in health and diabetesSemantic proximity Read ↗

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetesSemantic proximity Read ↗

Molecular regulation of pancreatic β-cell mass development, maintenance, and expansionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.