Article
HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.
Scientific reports - 2 Jun 2022
Mitani Yosuke, Ohashi Shinya, Kikuchi Osamu, Nakai Yukie, Ida Tomomi, Mizumoto Ayaka, Yamamoto Yoshihiro, Saito Tomoki, Kataoka Shigeki, Matsubara Junichi, Yamada Atsushi, Kanai Masashi, Matsumoto Shigemi, Sakai Hiroaki, Yoshikawa Kiyotsugu, Nakamura Eijiro, Muto Manabu
Abstract excerpt
Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiology, however, such interactions have not been fully elucidated. Additionally, the effect of target therapy for those variants also unclarified. In this study, we investigated...
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