Article
Familial Adrenocortical Carcinoma in Association With Lynch Syndrome.
The Journal of clinical endocrinology and metabolism - 1 Jun 2016
Challis Benjamin G, Kandasamy Narayanan, Powlson Andrew S, Koulouri Olympia, Annamalai Anand Kumar, Happerfield Lisa, Marker Alison J, Arends Mark J, Nik-Zainal Serena, Gurnell Mark
Abstract excerpt
CONTEXT: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of inherited cancer susceptibility syndromes, it remains less clear whether a hereditary tumor predisposition exists for the development of ACC in adults. Here, we report the first occurrence of familial ACC in a kindred with Lynch syndrome resulting from a...
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