Article
EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression.
Human molecular genetics - 1 Jul 2016
Drelon Coralie, Berthon Annabel, Mathieu Mickael, Ragazzon Bruno, Kuick Rork, Tabbal Houda, Septier Amandine, Rodriguez Stéphanie, Batisse-Lignier Marie, Sahut-Barnola Isabelle, Dumontet Typhanie, Pointud Jean-Christophe, Lefrançois-Martinez Anne-Marie, Baron Silvère, Giordano Thomas J, Bertherat Jérôme, Martinez Antoine, Val Pierre
Abstract excerpt
Adrenal Cortex Carcinoma (ACC) is an aggressive tumour with poor prognosis. Common alterations in patients include constitutive WNT/β-catenin signalling and overexpression of the growth factor IGF2. However, the combination of both alterations in transgenic mice is not sufficient to trigger malignant tumour progression, suggesting that other alterations are required to allow development of carcinomas. Here, we...
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