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Article

Case report of adrenocortical carcinoma associated with double germline mutations in MSH2 and RET.

American journal of medical genetics. Part A - 1 Apr 2021

Raygada Margarita, Raffeld Mark, Bernstein Andrew, Miettinen Markku, Glod John, Hughes Marybeth S, Reilly Karlyne, Widemann Brigitte, Del Rivero Jaydira

Abstract excerpt

Adrenocortical carcinoma (ACC) is a rare aggressive malignancy that originates in the outer layer of the adrenal gland. Most ACCs are sporadic, but a small percentage of cases are due to hereditary cancer syndromes such as Li-Fraumeni syndrome (LFS), Lynch syndrome (LS), and familial adenomatous polyposis (FAP). Multiple endocrine neoplasia type 2A (MEN2A) is an inherited disorder that predisposes to medullary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33615670
DOI: 10.1002/ajmg.a.62099
PMCID: PMC7986073

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