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Article

Characteristics of Adrenocortical Carcinoma Associated With Lynch Syndrome

13 Nov 2020

Abstract excerpt

CONTEXT: Lynch syndrome (LS) is the most common inherited colorectal and endometrial cancer syndrome, caused by germline mutations in DNA mismatch repair (MMR) genes. It is also characterized by an increased risk of other tumors with lower prevalence, such as adrenal cortical carcinoma (ACC), an endocrine tumor with an incidence of <2 cases/million individuals/year. Most ACC developed during childhood are...

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PMID: 33185660
DOI: 10.1210/clinem/dgaa833

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