Article
High-content analysis of microRNAs involved in the phenotype regulation of vascular smooth muscle cells.
Scientific reports - 3 Mar 2022
Zhang Jian, Starkuviene Vytaute, Erfle Holger, Wang Zhaohui, Gunkel Manuel, Zeng Ziwei, Sticht Carsten, Kan Kejia, Rahbari Nuh, Keese Michael
Abstract excerpt
In response to vascular injury vascular smooth muscle cells (VSMCs) alternate between a differentiated (contractile) and a dedifferentiated (synthetic) state or phenotype. Although parts of the signaling cascade regulating the phenotypic switch have been described, the role of miRNAs is still incompletely understood. To systematically address this issue, we have established a microscopy-based quantitative assay...
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