Riches of phenotype computationally extracted from microbial colonies.

doi:10.1073/pnas.1523295113

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Article

Riches of phenotype computationally extracted from microbial colonies.

Proceedings of the National Academy of Sciences of the United States of America - 17 May 2016

Liu Tzu-Yu, Dodson Anne E, Terhorst Jonathan, Song Yun S, Rine Jasper

Abstract excerpt

The genetic, epigenetic, and physiological differences among cells in clonal microbial colonies are underexplored opportunities for discovery. A recently developed genetic assay reveals that transient losses of heterochromatic repression, a heritable form of gene silencing, occur throughout the growth of Saccharomyces colonies. This assay requires analyzing two-color fluorescence patterns in yeast colonies, which...

Topics

Algorithms
Biological Assay
Gene Expression Regulation, Fungal
Gene Silencing
Genes, Reporter
Green Fluorescent Proteins
Image Processing, Computer-Assisted
Phenotype
Saccharomyces cerevisiae

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Identifiers

PMID: 27140647
DOI: 10.1073/pnas.1523295113
PMCID: PMC4878510

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