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Article

Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.

Journal of virology - 1 Jun 2010

Ferrer-Orta Cristina, Sierra Macarena, Agudo Rubén, de la Higuera Ignacio, Arias Armando, Pérez-Luque Rosa, Escarmís Cristina, Domingo Esteban, Verdaguer Nuria

Abstract excerpt

Passage of poliovirus (PV) or foot-and-mouth disease virus (FMDV) in the presence of ribavirin selected for viruses with decreased sensitivity to R, which included different mutations in their polymerase (3D): G64S located in the finger subdomain in the case of PV and M296I located within loop beta9-alpha11 at the active site in the case of FMDV. To investigate why disparate substitutions were selected in two...

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Identifiers

PMID: 20392853
DOI: 10.1128/JVI.02420-09
PMCID: PMC2876637

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