Article
Embracing the complexity of matricellular proteins: the functional and clinical significance of splice variation.
Biomolecular concepts - 1 May 2016
Viloria Katrina, Hill Natasha J
Abstract excerpt
Matricellular proteins influence wide-ranging fundamental cellular processes including cell adhesion, migration, growth and differentiation. They achieve this both through interactions with cell surface receptors and regulation of the matrix environment. Many matricellular proteins are also associated with diverse clinical disorders including cancer and diabetes. Alternative splicing is a precisely regulated...
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