Article

Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target- annotated reference chemicals in renal proximal tubular epithelial cells

2026-08-14

Abstract excerpt

Integrating high-throughput in vitro data into next-generation risk assessment (NGRA) workflows requires screening strategies that yield quantitative potency estimates and mechanistically interpretable biological signals. Transcriptomic and morphological profiling are increasingly adopted for early-stage hazard identification by enabling triage of substances for resource-intensive follow-up and prioritizing candid...

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Literature Corpus work: 7e444d39-f7bf-5e15-b83b-a2b21615fff2
DOI: 10.64898/2026.08.08.743660

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