Article
An association analysis of the R1628P and G2385R polymorphisms of the LRRK2 gene in multiple system atrophy in a Chinese population.
Parkinsonism & related disorders - 1 Feb 2015
Yuan XiaoQin, Chen YongPing, Cao Bei, Zhao Bi, Wei QianQian, Guo XiaoYan, Yang Yuan, Yuan LiXing, Shang HuiFang
Abstract excerpt
BACKGROUND: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been reported to be responsible for autosomal dominant late-onset sporadic Parkinson's disease (PD). The R1628P and G2385R polymorphisms of the LRRK2 gene have been identified as exclusively associated with PD in Asian populations, particularly in Han Chinese population. Considering that there is overlap of the clinical manifestations and...
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