Article

Heterogeneity of acetylcholine receptor autoantibody-mediated complement activity in patients with myasthenia gravis

2021-10-07

Abstract excerpt

<h4>Background</h4> Autoantibodies targeting the acetylcholine receptor (AChR), found in patients with myasthenia gravis (MG), mediate pathology through three mechanisms: complement-directed tissue damage, blocking of the acetylcholine binding site, and internalization of the AChR. Clinical assays, used to diagnose and monitor patients, measure only autoantibody binding. Consequently, they are limited in providing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 73ef2e81-e5d5-5166-b659-7dae51147195
DOI: 10.1101/2021.10.05.21264566

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Heterogeneity of acetylcholine receptor autoantibody-mediated complement activity in patients with myasthenia gravisDOI 10.1101/2021.10.05.21264566Read

Distribution and Temporal Changes of Autoantibody-Mediated Pathogenic Mechanisms Among Acetylcholine Receptor-Positive Myasthenia Gravis PatientsSemantic proximity Read

Receptor clustering and pathogenic complement activation in myasthenia gravis depend on synergy between antibodies with multiple subunit specificitiesSemantic proximity Read

A primary human muscle cell-based assay for detecting myasthenia gravis autoantibody binding and assessing AChR cluster impairmentSemantic proximity Read

Myasthenia gravis: from autoantibodies to therapy.Semantic proximity Read

Identification of disease phenotypes in acetylcholine receptor-antibody myasthenia gravis using proteomics-based consensus clustering.Semantic proximity Read

Pathogenesis of myasthenia gravis: update on disease types, models, and mechanismsSemantic proximity Read

Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signatureSemantic proximity Read

Clinical Features and Diagnostic Usefulness of Antibodies to Clustered Acetylcholine Receptors in the Diagnosis of Seronegative Myasthenia Gravis.Semantic proximity Read

Clinical Genomic, phenotype and epigenetic insights into the pathology, autoimmunity and weight management of patients with Myasthenia Gravis (Review).Semantic proximity Read

The role of complement in the immunopathogenesis of acetylcholine receptor antibody-positive generalized myasthenia gravis: bystander or key player?Semantic proximity Read

Diagnostic Performance of ELISA and RIA in AChR Antibody Testing for Myasthenia Gravis: A Real- World Cohort StudySemantic proximity Read

Phenotype, Severity, and Therapy of Patients With LRP4 Antibody-Associated Myasthenia Gravis in the German Myasthenia Gravis Registry.Semantic proximity Read