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Septin‐5 and ‐ 7‐IgGs : Neurologic, Serologic, and Pathophysiologic Characteristics

15 Aug 2022

Abstract excerpt

BACKGROUND AND OBJECTIVES: We sought to determine clinical significance of neuronal septin autoimmunity and evaluate for potential IgG effects. METHODS: Septin-IgGs were detected by indirect immunofluorescence assays (IFAs; mouse tissue and cell based) or Western blot. IgG binding to (and internalization of) extracellular septin epitopes were evaluated for by live rat hippocampal neuron assay. The impact of...

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PMID: 36053822
DOI: 10.1002/ana.26482

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