Article
Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Wang Yanni, Thomson Christy A, Allan Lenka L, Jackson Linda M, Olson Melanie, Hercus Timothy R, Nero Tracy L, Turner Amanda, Parker Michael W, Lopez Angel L, Waddell Thomas K, Anderson Gary P, Hamilton John A, Schrader John W
Abstract excerpt
The origin of pathogenic autoantibodies remains unknown. Idiopathic pulmonary alveolar proteinosis is caused by autoantibodies against granulocyte-macrophage colony-stimulating factor (GM-CSF). We generated 19 monoclonal autoantibodies against GM-CSF from six patients with idiopathic pulmonary alveolar proteinosis. The autoantibodies used multiple V genes, excluding preferred V-gene use as an etiology, and...
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