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Article

Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG

4 Dec 2019

Abstract excerpt

Purkinje cell cytoplasmic antibody type-2 (PCA2-IgG) was first defined as a paraneoplastic biomarker based on a unique immunofluorescence pattern seen on a mouse composite brain tissue assay.1 Lung and breast cancer are the most common malignancies associated with PCA2-IgG seropositivity.2 In 2017, microtubule-associated protein 1B (MAP1B) protein was identified as the autoantigen target for PCA2-IgG.2 Clinical...

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PMID: 31801846
DOI: 10.1136/jnnp-2019-322175

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