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Article

Comparison of acetaminophen toxicity in primary hepatocytes isolated from transgenic mice with different appolipoprotein E alleles.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society - 1 Dec 2015

Mezera V, Kucera O, Moravcova A, Peterova E, Rousar T, Rychtrmoc D, Sobotka O, Cervinkova Z

Abstract excerpt

The nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, important for combating electrophilic and oxidative stress in the liver and other organs. This encompasses detoxification of hepatotoxic drugs, including acetaminophen (APAP). Recently, an association between apolipoprotein E (ApoE) genotype and Nrf2 expression was described. We compared the toxicity of APAP on primary culture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26769836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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