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UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma

19 Jun 2018

Abstract excerpt

Ubiquitin-conjugating enzyme E2S (UBE2S) plays pivotal roles in the progression of human cancers. However, its clinical significance and role in hepatocellular carcinoma (HCC) remain unknown. Here, we show that UBE2S is upregulated in HCC and exhibits oncogenic activities via enhancing the ubiquitination of p53. Increased expression of UBE2S was significantly correlated with higher serum AFP level, higher...

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PMID: 29928880
DOI: 10.1016/j.bbrc.2018.06.093

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