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Article

Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jul 2016

Ravenscroft Stephanie M, Pointon Amy, Williams Awel W, Cross Michael J, Sidaway James E

Abstract excerpt

The immature phenotype of stem cell derived cardiomyocytes is a significant barrier to their use in translational medicine and pre-clinical in vitro drug toxicity and pharmacological analysis. Here we have assessed the contribution of non-myocyte cells on the contractile function of co-cultured human embryonic stem cell derived cardiomyocytes (hESC-CMs) in spheroid microtissue format. Microtissues were formed...

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Identifiers

PMID: 27125969
DOI: 10.1093/toxsci/kfw069
PMCID: PMC4922542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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