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Coculture with noncardiac cells promoted maturation of human stem cell–derived cardiomyocyte microtissues

14 May 2019

Abstract excerpt

Cardiomyocytes derived from human pluripotent stem cells (hPSC-CM) provided a promising cell source for cell therapy, drug screening, and disease modeling. However, hPSC-CM are immature and phenotypically more similar to fetal rather than adult cardiomyocytes in vitro. We explored the impact of coculture of human embryonic stem cell-derived mesenchymal stem cells (hESC-MSC) and endothelial cells (ECs) with human...

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PMID: 31090105
DOI: 10.1002/jcb.28926

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