Article
Proteomic mapping of p53 immunogenicity in pancreatic, ovarian, and breast cancers.
Proteomics. Clinical applications - 1 Jul 2016
Katchman Benjamin A, Barderas Rodrigo, Alam Rizwan, Chowell Diego, Field Matthew S, Esserman Laura J, Wallstrom Garrick, LaBaer Joshua, Cramer Daniel W, Hollingsworth Michael A, Anderson Karen S
Abstract excerpt
PURPOSE: Mutations in TP53 induce autoantibody immune responses in a subset of cancer patients, which have been proposed as biomarkers for early detection. Here, we investigate the association of p53-specific autoantibodies with multiple tumor subtypes and determine the association with p53 mutation status and epitope specificity. EXPERIMENTAL DESIGN: IgG p53 autoantibodies (p53-AAb), were quantified in 412 serum...
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