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Autoantibody Signature for the Serologic Detection of Ovarian Cancer

3 Nov 2014

Abstract excerpt

Sera from patients with ovarian cancer contain autoantibodies (AAb) to tumor-derived proteins that are potential biomarkers for early detection. To detect AAb, we probed high-density programmable protein microarrays (NAPPA) expressing 5177 candidate tumor antigens with sera from patients with serous ovarian cancer (n = 34 cases/30 controls) and measured bound IgG. Of these, 741 antigens were selected and probed...

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PMID: 25365139
DOI: 10.1021/pr500908n

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