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Article

Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population

16 Dec 2008

Abstract excerpt

During development, renal stem cells reside in the nephrogenic blastema. Wilms' tumour (WT), a common childhood malignancy, is suggested to arise from the nephrogenic blastema that undergoes partial differentiation and as such is an attractive model to study renal stem cells leading to cancer initiation and maintenance. Previously we have made use of blastema-enriched WT stem-like xenografts propagated in vivo to...

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PMID: 20187302
DOI: 10.1111/j.1582-4934.2008.00607.x

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