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Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

17 Feb 2020

Abstract excerpt

Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-thirds of patients with metastases progress within two years. Here we report the identification and characterization of a cancer stem cell (CSC) population in ccRCC. CSCs are quantitatively correlated with tumor aggressiveness and metastasis. Transcriptional profiling and single cell sequencing reveal that these CSCs exhibit...

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PMID: 32066735
DOI: 10.1038/s41467-020-14700-7

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