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Article

Oncogenic ALK regulates EMT in non-small cell lung carcinoma through repression of the epithelial splicing regulatory protein 1.

Oncotarget - 31 May 2016

Voena Claudia, Varesio Lydia M, Zhang Liye, Menotti Matteo, Poggio Teresa, Panizza Elena, Wang Qi, Minero Valerio G, Fagoonee Sharmila, Compagno Mara, Altruda Fiorella, Monti Stefano, Chiarle Roberto

Abstract excerpt

A subset of Non-Small Cell Lung Carcinoma (NSCLC) carries chromosomal rearrangements involving the Anaplastic Lymphoma Kinase (ALK) gene. ALK-rearranged NSCLC are typically adenocarcinoma characterized by a solid signet-ring cell pattern that is frequently associated with a metastatic phenotype. Recent reports linked the presence of ALK rearrangement to an epithelial-mesenchymal transition (EMT) phenotype in...

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Source

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Identifiers

PMID: 27119231
DOI: 10.18632/oncotarget.8955
PMCID: PMC5078097

Genes

ALK
EML4
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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