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Article

TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.

PloS one - 1 Jan 2012

Pallier Karine, Cessot Anatole, Côté Jean-Francois, Just Pierre-Alexandre, Cazes Aurélie, Fabre Elizabeth, Danel Claire, Riquet Marc, Devouassoux-Shisheboran Mojgan, Ansieau Stéphane, Puisieux Alain, Laurent-Puig Pierre, Blons Hélène

Abstract excerpt

Metastasis is a multistep process and the main cause of mortality in lung cancer patients. We previously showed that EGFR mutations were associated with a copy number gain at a locus encompassing the TWIST1 gene on chromosome 7. TWIST1 is a highly conserved developmental gene involved in embryogenesis that may be reactivated in cancers promoting both malignant conversion and cancer progression through an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22272264
DOI: 10.1371/journal.pone.0029954
PMCID: PMC3260187

Genes

TWIST1
EGFR
EGF
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma.PMID 22272264Read ↗

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Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancerSemantic proximity Read ↗

Prognostic Significance of Twist and N-Cadherin Expression in NSCLCSemantic proximity Read ↗

A twist tale of cancer metastasis and tumor angiogenesis.Semantic proximity Read ↗

Differential expression and activation of epidermal growth factor receptor 1 (EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC).Semantic proximity Read ↗

Overexpression of MEOX2 and TWIST1 Is Associated with H3K27me3 Levels and Determines Lung Cancer Chemoresistance and PrognosisSemantic proximity Read ↗

Epithelial‐to‐mesenchymal transition in the context of epidermal growth factor receptor inhibition in non‐small‐cell lung cancerSemantic proximity Read ↗

Direct regulation of TWIST by HIF-1alpha promotes metastasis.Semantic proximity Read ↗

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