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Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression

9 Oct 2018

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is the most frequent and malignant primary brain tumor in adults and despite the progress in surgical procedures and therapy options, the overall survival remains very poor. Glutamate and α-KG are fundamental elements necessary to support the growth and proliferation of GBM cells. Glutamate oxidative deamination, catalyzed by GLUD2, is the predominant pathway for the production of...

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PMID: 30314897
DOI: 10.1016/j.ebiom.2018.10.008

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