Article
In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale - 26 Apr 2016
Rudy Shannon F, Brenner J Chad, Harris Jennifer L, Liu Jun, Che Jianwei, Scott Megan V, Owen John Henry, Komarck Christine M, Graham Martin P, Bellile Emily L, Bradford Carol R, Prince Mark E P, Carey Thomas E
Abstract excerpt
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic...
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