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Article

Wnt signaling dynamics in head and neck squamous cell cancer tumor‐stroma interactions

31 Oct 2018

Abstract excerpt

Wnt pathway activation maintains the cancer stem cell (CSC) phenotype and promotes tumor progression, making it an attractive target for anti-cancer therapy. Wnt signaling at the tumor and tumor microenvironment (TME) front have not been investigated in depth in head and neck squamous cell carcinoma (HNSCC). In a cohort of 48 HNSCCs, increased Wnt signaling, including Wnt genes (AXIN2, LGR6, WISP1) and stem cell...

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PMID: 30378175
DOI: 10.1002/mc.22937

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