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Article

Characterization of TNF-α- and IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IκBζ.

The Journal of investigative dermatology - 1 Aug 2016

Johansen Claus, Bertelsen Trine, Ljungberg Christine, Mose Maike, Iversen Lars

Abstract excerpt

Human β-defensin 2 (hBD2), encoded by the DEFB4 gene, is an antimicrobial peptide playing an essential role in inflammatory processes in the skin. hBD2 expression is regulated synergistically by tumor necrosis factor-α (TNF-α) and IL-17A; however, the underlying regulatory mechanisms are unknown. The purpose of this study was to characterize the molecular mechanism by which TNF-α and IL-17A synergistically induce...

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Source

Identifiers

PMID: 27117051
DOI: 10.1016/j.jid.2016.04.012

Genes

TNF
CCL20
LCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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