Article
Regulation of IL-17A production is distinct from IL-17F in a primary human cell co-culture model of T cell-mediated B cell activation.
PloS one - 1 Jan 2013
Melton Andrew C, Melrose Jennifer, Alajoki Liisa, Privat Sylvie, Cho Hannah, Brown Naomi, Plavec Ana Marija, Nguyen Dat, Johnston Elijah D, Yang Jian, Polokoff Mark A, Plavec Ivan, Berg Ellen L, O'Mahony Alison
Abstract excerpt
Improper regulation of B cell responses leads to excessive production of antibodies and contributes to the development of autoimmune disease. T helper 17 (Th17) cells also drive the development of autoimmune disease, but the role of B cells in shaping Th17 cell-mediated immune responses, as well as the reciprocal regulation of B cell responses by IL-17 family cytokines, remains unclear. The aim of this study was...
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