Article

Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells

1999-12-01

Abstract excerpt

Abstract The C-C chemokine eotaxin is a potent chemoattractant for eosinophils and probably plays an important role in the pathogenesis of asthma, although the mechanisms of its regulation are not well known. Airway epithelial cells express eotaxin mRNA and protein after stimulation with a variety of cytokines. We focused on the molecular mechanisms of eotaxin gene regulation by TNF-α and IL-4 in the airway epithe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e35ef654-237f-5485-acc0-385ef2813040
DOI: 10.4049/jimmunol.163.12.6876

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial CellsDOI 10.4049/jimmunol.163.12.6876Read

beta2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation.Semantic proximity Read

Human dermal fibroblasts express eotaxin: molecular cloning, mRNA expression, and identification of eotaxin sequence variants.Semantic proximity Read

Inflammatory Modulation of Bronchial Epithelial Cells’ Response to Lipopolysaccharide with Pretreatment by MontelukastSemantic proximity Read

A single nucleotide polymorphism on the promoter of eotaxin1 associates with its mRNA expression and asthma phenotypes.Semantic proximity Read

Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.Semantic proximity Read

A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levelsSemantic proximity Read

Characterization of TNF-α- and IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IκBζ.Semantic proximity Read

Antigen-induced eosinophilic lung inflammation develops in mice deficient in chemokine eotaxin.Semantic proximity Read

Epigenetic Regulation of the IL-13-induced Human Eotaxin-3 Gene by CREB-binding Protein-mediated Histone 3 AcetylationSemantic proximity Read

Role of transcription factors in inflammatory lung diseasesSemantic proximity Read

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.Semantic proximity Read

Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation.Semantic proximity Read