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Article

EGFR ligands synergistically increase IL‐17A‐induced expression of psoriasis signature genes in human keratinocytes via IκBζ and Bcl3

12 Apr 2022

Abstract excerpt

Various epidermal growth factor receptor (EGFR) ligands are highly expressed in the epidermis of psoriasis lesions, and abnormal EGFR activation appears to be involved in the pathogenesis of psoriasis. However, how EGFR signaling contributes to the development of psoriasis is unclear. Interleukin (IL)-17A, a critical effector of the IL-23/IL-17A pathway, increases the expression of psoriasis signature genes in...

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PMID: 35411943
DOI: 10.1002/eji.202149706

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EGFR ligands synergistically increase IL‐17A‐induced expression of psoriasis signature genes in human keratinocytes via IκBζ and Bcl3PMID 35411943Read ↗

IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytesSemantic proximity Read ↗

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Integrative Responses to IL-17 and TNF-α in Human Keratinocytes Account for Key Inflammatory Pathogenic Circuits in PsoriasisSemantic proximity Read ↗

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miR ‐378a regulates keratinocyte responsiveness to interleukin‐17A in psoriasis*Semantic proximity Read ↗

The Pro-Inflammatory Cytokine IL-22 Up-Regulates Keratin 17 Expression in Keratinocytes via STAT3 and ERK1/2Semantic proximity Read ↗

Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?Semantic proximity Read ↗

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.Semantic proximity Read ↗

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