Article
Metastatic Disease in Polyploid Uveal Melanoma Patients Is Associated With BAP1 Mutations.
Investigative ophthalmology & visual science - 1 Apr 2016
Yavuzyigitoglu Serdar, Mensink Hanneke W, Smit Kyra N, Vaarwater Jolanda, Verdijk Robert M, Beverloo Berna, Brüggenwirth Hennie T, van Marion Ronald, Dubbink Hendrikus J, Paridaens Dion, Naus Nicole C, de Klein Annelies, Kiliç Emine
Abstract excerpt
PURPOSE: Most of the uvea melanoma (UM) display a near-diploid (normal, -2N) karyotype with only a few chromosomal changes. In contrast to these simple aberrations 18% of the UM samples show a polyploid character (>2N) and this was associated with an unfavorable prognosis. This study attempts to gain insight in the prognostic value of polyploidy in UM. METHODS: In 202 patients the ploidy status of the UM was...
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