Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.

JAMA ophthalmology - 1 Jul 2016

Decatur Christina L, Ong Erin, Garg Nisha, Anbunathan Hima, Bowcock Anne M, Field Matthew G, Harbour J William

Abstract excerpt

IMPORTANCE: Frequent mutations have been described in the following 5 genes in uveal melanoma (UM): BAP1, EIF1AX, GNA11, GNAQ, and SF3B1. Understanding the prognostic significance of these mutations could facilitate their use in precision medicine. OBJECTIVE: To determine the associations between driver mutations, gene expression profile (GEP) classification, clinicopathologic features, and patient outcomes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Melanoma
Share to Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoproteins

Share to RNA Splicing Factors

Share to Tumor Suppressor Proteins

Share to Ubiquitin Thiolesterase

Share to Uveal Melanoma

Share to Uveal Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27123562
DOI: 10.1001/jamaophthalmol.2016.0903
PMCID: PMC4966162

Genes

BAP1
GNA11
GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Driver Mutations in Uveal Melanoma: Associations With Gene Expression Profile and Patient Outcomes.PMID 27123562Read ↗

The genetics of uveal melanoma: current insightsSemantic proximity Read ↗

Bioinformatics analysis of GNAQ, GNA11, BAP1, SF3B1,SRSF2, EIF1AX, PLCB4, and CYSLTR2 genes and their role in the pathogenesis of Uveal Melanoma.Semantic proximity Read ↗

Pathological and Molecular Diagnosis of Uveal MelanomaSemantic proximity Read ↗

Uveal melanoma: epidemiology, etiology, and treatment of primary diseaseSemantic proximity Read ↗

Genomic, prognostic, and cell-signaling advances in uveal melanoma.Semantic proximity Read ↗

Current molecular and clinical insights into uveal melanoma (Review).Semantic proximity Read ↗

Molecular profiling of primary uveal melanoma: results of a Polish cohort.Semantic proximity Read ↗

Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma.Semantic proximity Read ↗

Genetics and RNA Regulation of Uveal MelanomaSemantic proximity Read ↗

Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic ApproachesSemantic proximity Read ↗

Clinical and genetic characteristics of BAP1-mutated non-uveal and uveal melanoma.Semantic proximity Read ↗

Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal MelanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.