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Aberrant DNA Methylation: Implications in Racial Health Disparity

25 Apr 2016

Abstract excerpt

BACKGROUND: Incidence and mortality rates of colorectal carcinoma (CRC) are higher in African Americans (AAs) than in Caucasian Americans (CAs). Deficient micronutrient intake due to dietary restrictions in racial/ethnic populations can alter genetic and molecular profiles leading to dysregulated methylation patterns and the inheritance of somatic to germline mutations. MATERIALS AND METHODS: Total DNA and RNA...

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PMID: 27111221
DOI: 10.1371/journal.pone.0153125

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