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DNA methylation profiling at base-pair resolution reveals unique epigenetic features of early-onset colorectal cancer in underrepresented populations

22 Jan 2025

Abstract excerpt

BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC) has been rising at an alarming rate in the USA, and EOCRC disproportionately affects racial/ethnic minorities. Here, we construct comprehensive profiles of EOCRC DNA methylomes at base-pair resolution for a cohort of Hispanic and African American patients. RESULTS: We show the epigenetic landscape of these EOCRC patients differs from that of...

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PMID: 39844333
DOI: 10.1186/s13148-025-01817-z

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