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Article

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation.

Clinical immunology (Orlando, Fla.) - 1 Jul 2016

Rozmus Jacob, McDonald Rachel, Fung Shan-Yu, Del Bel Kate L, Roden Juliana, Senger Christof, Schultz Kirk R, McKinnon Margaret L, Davis Jeffrey, Turvey Stuart E

Abstract excerpt

MALT1 mutations impair normal NF-κB activation and paracaspase activity to cause a novel combined immunodeficiency. The clinical and immunological phenotype of MALT1 deficiency can be successfully treated with hematopoietic stem cell transplantation following reduced intensity conditioning.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27109639
DOI: 10.1016/j.clim.2016.04.011

Genes

MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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