Article
Clinical and immunological correction of DOCK8 deficiency by allogeneic hematopoietic stem cell transplantation following a reduced toxicity conditioning regimen.
Pediatric hematology and oncology - 1 Oct 2012
Boztug Heidrun, Karitnig-Weiß Cäcilia, Ausserer Bernd, Renner Ellen D, Albert Michael H, Sawalle-Belohradsky Julie, Belohradsky Bernd H, Mann Georg, Horcher Ernst, Rümmele-Waibel Alexandra, Geyeregger Rene, Lakatos Karoly, Peters Christina, Lawitschka Anita, Matthes-Martin Susanne
Abstract excerpt
Dedicator of cytokinesis 8 protein (DOCK8) deficiency is a combined immunodeficiency disorder characterized by an expanding clinical picture with typical features of recurrent respiratory or gastrointestinal tract infections, atopic eczema, food allergies, chronic viral infections of the skin, and blood eosinophilia often accompanied by elevated serum IgE levels. The only definitive treatment option is allogeneic...
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