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Article

The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [(11)C]DASB positron emission tomography study.

Neuropharmacology - 1 Nov 2016

Hinderberger Philipp, Rullmann Michael, Drabe Mandy, Luthardt Julia, Becker Georg-Alexander, Blüher Matthias, Regenthal Ralf, Sabri Osama, Hesse Swen

Abstract excerpt

BACKGROUND: Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Moreover, a polymorphism (5-HTTLPR) in the serotonin reuptake transporter (5-HTT) gene impairs its transcription, thereby altering serotonergic tone and potentially contributing to such susceptibility. This study aims to...

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Source

Identifiers

PMID: 27108933
DOI: 10.1016/j.neuropharm.2016.04.030

Genes

BDNF
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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