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Article

BDNF Val66Met polymorphism is linked to elevated levels of serotonin-transporter in the medial prefrontal cortex but not to altered eating behavior.

Neuroscience - 7 May 2026

McLeod Anke, Rullmann Michael, Hinderberger Philipp, Böttcher Yvonne, Müller Ines, Hankir Mohammed K, Becker Georg-Alexander, Blüher Matthias, Regenthal Ralf, Hilbert Anja, Sabri Osama, Hesse Swen

Abstract excerpt

A single nucleotide polymorphism in the brain derived neurotrophic factor (BDNF)-encoding gene leads to diminished BDNF signaling resulting from Val66Met and has been linked to obesity. Previous imaging studies regarding the impact of BDNF Val66Met on the central serotonin system, which is involved in behavior, cognition and control of satiety, have not focused on body weight or food-intake related behavior. We...

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PMID: 41802488
DOI: 10.1016/j.neuroscience.2026.03.008

Genes

BDNF
HTT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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BDNF Val66Met polymorphism is linked to elevated levels of serotonin-transporter in the medial prefrontal cortex but not to altered eating behavior.PMID 41802488Read ↗

The effect of serum BDNF levels on central serotonin transporter availability in obese versus non-obese adults: A [(11)C]DASB positron emission tomography study.Semantic proximity Read ↗

The BDNF Val66Met polymorphism serves as a potential marker of body weight in patients with psychiatric disordersSemantic proximity Read ↗

Food restriction leads to binge eating dependent upon the effect of the brain-derived neurotrophic factor Val66Met polymorphism.Semantic proximity Read ↗

The interaction effect between BDNF val66met polymorphism and obesity on executive functions and frontal structure.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

Influence of BDNF Val66Met genetic polymorphism in Major Depressive Disorder and Body Mass Index: Evidence from a meta-analysis of 6481 individuals.Semantic proximity Read ↗

BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice.Semantic proximity Read ↗

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Genetic variation in brain-derived neurotrophic factor val66met allele is associated with altered serotonin-1A receptor binding in human brain.Semantic proximity Read ↗

Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.Semantic proximity Read ↗

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