Article
A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages.
Neoplasia (New York, N.Y.) - 1 Apr 2016
Kobayashi Kana, Yano Hajime, Umakoshi Akihiro, Matsumoto Shirabe, Mise Ayano, Funahashi Yu, Ueno Yoshitomo, Kamei Yoshiaki, Takada Yasutsugu, Kumon Yoshiaki, Ohnishi Takanori, Tanaka Junya
Abstract excerpt
CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L) but also its truncated form, CD200S. Although CD200S is reported to antagonize the immunosuppressive actions of CD200L, the role of CD200S in tumor immunity has never been investigated. We established rat...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.