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Article

The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.

Cancer research - 1 Oct 2021

Khan Iasha Z, Del Guzzo Christina A, Shao Anqi, Cho Jiyoon, Du Rong, Cohen Adrienne O, Owens David M

Abstract excerpt

The CD200-CD200R immunoregulatory signaling axis plays an etiologic role in the survival and spread of numerous cancers, primarily through suppression of antitumor immune surveillance. Our previous work outlined a prometastatic role for the CD200-CD200R axis in cutaneous squamous cell carcinoma (cSCC) that is independent of direct T-cell suppression but modulates the function of infiltrating myeloid cells. To...

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Topics

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Share to Antigens, CD
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsin K

Share to Fluorescent Antibody Technique

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Share to Membrane Glycoproteins

Share to Myeloid-Derived Suppressor Cells

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Source

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Identifiers

PMID: 34183355
DOI: 10.1158/0008-5472.CAN-20-3251
PMCID: PMC8488015

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