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Article

Loss of Sparc in p53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival.

Brain pathology (Zurich, Switzerland) - 1 Jul 2015

Thomas Stacey L, Schultz Chad R, Mouzon Ezekiell, Golembieski William A, El Naili Reima, Radakrishnan Archanna, Lemke Nancy, Poisson Laila M, Gutiérrez Jorge A, Cottingham Sandra, Rempel Sandra A

Abstract excerpt

Both the induction of SPARC expression and the loss of the p53 tumor suppressor gene are changes that occur early in glioma development. Both SPARC and p53 regulate glioma cell survival by inverse effects on apoptotic signaling. Therefore, during glioma formation, the upregulation of SPARC may cooperate with the loss of p53 to enhance cell survival. This study determined whether the loss of Sparc in astrocytes...

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Identifiers

PMID: 24862407
DOI: 10.1111/bpa.12161
PMCID: PMC4520390

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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